Outbreak Update: Since the last brief (14 September 2021), 3,862,133 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 62,740 new deaths, have been reported globally. To date, a global total of 228,401,433 COVID-19 cases and 4,690,961 related deaths (case fatality ratio (CFR): 2.1%) have been reported from 225 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 13,164,909 (6%), European Region 68,419,751 (30%), Region of the Americas 88,054,178 (39%), South-East Asia Region 42,547,959 (19%) and Western Pacific Region 7,975,252 (3%). In the last seven days, the five countries reporting the highest number of new cases globally are the United States (950,031), Brazil (241,161), India (214,244), the United Kingdom (203,470), and Turkey (189,008). For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.