Outbreak Update: Since the last brief (24 August 2021), 4,566,357 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 67,160 new deaths, have been reported globally. To date, a global total of 216,340,385 COVID-19 cases and 4,498,657 related deaths (case fatality ratio (CFR): 2.1%) have been reported from 225 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 12,381,559 (6%), European Region 64,991,125 (30%), Region of the Americas 83,479,049 (39%), South-East Asia Region 41,178,198 (19%) and Western Pacific Region 6,478,375 (3%). In the last seven days, the five countries reporting the highest number of new cases globally are the United States (977,947), India (288,633), the Islamic Republic of Iran (249,850), the United Kingdom (238,517) and Brazil (172,118). For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.