Outbreak Update: Since the last brief (3 August 2021), 4,390,587 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 66,248 new deaths, have been reported globally. To date, a global total of 202,662,062 COVID-19 cases and 4,294,334 related deaths (case fatality ratio (CFR): 2.1%) have been reported from 225 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 11,245,002 (5%), European Region 61,333,662 (30%), Region of the Americas 78,718,104 (39%), South-East Asia Region 39,271,048 (19%) and Western Pacific Region 4,959,531 (2%). In the last seven days, the five countries reporting the highest number of new cases globally are the United States (705,033), India (273,996), Islamic Republic of Iran (255,210), Brazil (233,924) and Indonesia (223,940). For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.