Outbreak Update: Since the last brief (13 July 2021), 3,953,921 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 58,139 new deaths, have been reported globally. To date, a global total of 190,631,102 COVID-19 cases and 4,093,871 related deaths (case fatality ratio (CFR): 2.2%) have been reported from 225 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 10,172,760 (5%), European Region 58,439,992 (31%), Region of the Americas 74,832,520 (39%), South-East Asia Region 36,865,283 (19%) and Western Pacific Region 4,000,016 (2%). In the last seven days, the five countries reporting the highest number of new cases globally are Brazil (386,634), Indonesia (344,103), the United Kingdom (312,694), India (269,853) and the United States (189,267). For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.