Outbreak Update: Since the last brief (22 June 2021), 2,615,379 new confirmed coronavirus disease 2019 (COVID-19) cases, including 57,505 new deaths, have been reported globally. To date, a global total of 180,844,523 COVID-19 cases and 3,923,825 related deaths (case fatality ratio (CFR): 2.2%) have been reported from 225 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 9,443,683 (5%), European Region 55,763,610 (31%), Region of the Americas 71,957,777 (40%), South-East Asia Region 34,666,159 (19%) and Western Pacific Region 3,522,008 (2%). In the last seven days, Brazil reported more than 500,000 new cases, India reported more than 300,000 new cases, Colombia reported over 200,000 new cases, while Argentina, Indonesia and the Russian Federation reported more than 100,000 new cases. For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.