Outbreak Update: Since the last brief (13 April 2021), 5,397,279 new confirmed coronavirus disease 2019 (COVID-19) cases and 84,252 new deaths have been reported globally. To date, a total of 141,058,320 COVID-19 cases and 3,015,314 related deaths (case fatality ratio (CFR): 2.1%) have been reported from 225 countries and territories. The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 7,252,875 (5%), European Region 49,364,760 (35%), Region of the Americas 59,757,984 (42%), South-East Asia Region 17,981,667 (13%) and Western Pacific Region 2,224,974(2%). Over the last seven days, India reported more than 1,500,000 new cases, while Brazil, Turkey and the United States each reported more than 400,000 new cases. France, Iran, Argentina, Germany, Colombia, Poland and Italy have each reported more than 100,000 new cases during the same period. For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO daily situation reports.