Outbreak Update: Since the last brief (6 April 2021), 4,626,902 new confirmed coronavirus disease 2019 (COVID-19) cases and 80,223 new deaths have been reported globally. To date, a total of 135,661,041 COVID-19 cases and 2,931,062 related deaths (case fatality ratio (CFR): 2.2%) have been reported from 225 countries and territories. The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 6,905,701 (5%), European Region 47,723,272 (35%), Region of the Americas 58,179,645 (43%), South-East Asia Region 16,358,405 (12%) and Western Pacific Region 2,096,495(2%). Over the last seven days, India, Brazil, Turkey and the United States have each reported more than 300K new cases. While Argentina, Iran, France, Poland, Italy, Germany and Ukraine have each reported more than 100k new cases. For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO daily situation reports.