Since the last brief (26 January 2021), 3,792,402 new confirmed coronavirus disease 2019 (COVID-19) cases and 98,417 new deaths have been reported globally. To date, a total of 102,603,826 COVID-19 cases and 2,223,216 related deaths (case fatality rate (CFR): 2.2%) have been reported from 225 countries and territories. The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 4,694,035 (5%), European Region 34,316,553 (33%), Region of the Americas 45,555,879 (44%), South-East Asia Region 13,008,965 (13%) and Western Pacific Region 1,430,799 (1%). Among the affected locations, the United States has reported more than one million new cases each week for the last 12 consecutive weeks, while for the last seven days, Brazil reported over 300,000 new cases. For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO daily situation reports.