Outbreak Update: Since the last brief (13 October 2020), 2,524,173 new confirmed coronavirus disease 2019 (COVID-19) cases and 36,810 new deaths have been reported globally. To date, a total of 39,952,759 COVID-19 cases and 1,112,108 related deaths (case fatality rate (CFR): 2.8%) have been reported from 219 countries and territories. This week, one new territory, Wallis & Futuna, reported its first case. The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 2,377,444 (6%), European Region 8,027,640 (20%), Region of the Americas 18,709,984 (47%), South-East Asia Region 8,489,775 (21%) and Western Pacific Region 684,698 (2%). Among the affected locations, India, the United States, France, Brazil, the United Kingdom, and Russia have reported over 100,000 new cases over the past week. For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO daily situation reports.