Outbreak Update: As of 25 April 2022, a total of 507,275,762 COVID-19 cases and 6,219,701 deaths (case fatality ratio [CFR]: 1.2%) have been reported globally by 227 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (percentage of global cases) from the WHO regions (excluding Africa) are as follows: Eastern Mediterranean Region 18,356,261 (4%), European Region 213,208,305 (42%), Region of the Americas 152,536,900 (30%), South-East Asia Region 57,751,940 (11%) and Western Pacific Region 53,597,736 (11%). In the last seven days, the five countries reporting the highest number of new cases are Germany (662,310), the Republic of Korea (576,128), France (515,200), Italy (423,969) and the United States of America (293,396). Over 4.6 billion people (58% of the global population) have been fully vaccinated. For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.