Outbreak Update: Since the last brief (21 December 2021), 4,444,521 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 38,559 new deaths, have been reported globally. To date, a global total of 279,089,404 COVID-19 cases and 5,397,936 related deaths (case fatality ratio (CFR): 2%) have been reported by 226 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 14,575,179 (5%), European Region 97,546,769 (35%), Region of the Americas 101,370,646 (36%), South-East Asia Region 44,909,586 (16%) and Western Pacific Region 11,096,847 (4%). In the last seven days, the five countries reporting the highest number of new cases globally are the United States (1,180,930), the United Kingdom (529,905), France (483,886), Italy (258,158) and Germany (195,667). For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.