Outbreak Update: Since the last brief (14 December 2021), 4,501,031 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 47,740 new deaths, have been reported globally. To date, a global total of 273,869,899 COVID-19 cases and 5,352,069 related deaths (case fatality ratio (CFR): 2%) have been reported by 226 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 14,513,439 (5%), European Region 94,637,598 (35%), Region of the Americas 99,775,067 (36%), South-East Asia Region 44,833,250 (16%) and Western Pacific Region 10,824,481 (4%). In the last seven days, the five countries reporting the highest number of new cases globally are the United States (827,506), the United Kingdom (541,872), France (362,800), Germany (278,016) and the Russian Federation (195,358). For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.