Outbreak Update: Since the last brief (8 June 2021), no new cases or deaths of Ebola virus disease (EVD) have been reported in Guinea. Cumulatively 23 cases, 12 deaths (CFR: 52%), and 10 recoveries of EVD have been reported. This includes five health workers. The last confirmed EVD case and death was reported on 4 April 2021. A 42-day countdown started on 8 May 2021 to declare the end of Guinea’s EVD outbreak (4 days remaining). To date, all known contacts have been monitored. A total of 10,873 people have been vaccinated against Ebola virus in Guinea. Member States bordering Guinea continue to remain vigilant. Sierra Leone has reported 57 alerts since the onset of EVD in Guinea. Fifty-five of these alerts were investigated and tested negative for Ebola virus; two were notified after burial. A total of 2 025 frontline workers have been vaccinated against Ebola virus in Sierra Leone.