Africa has been highly affected by recurrent emerging and re-emerging public health threats such as Ebola, Marburg, Mpox, Measles, Dengue Fever, Cholera, COVID-19, and others. Learning from the COVID-19 pandemic response, Africa CDC, the only Pan-African Agency, highlights critical lessons learned during the response to the pandemic. In this article published in BMJ Global Health, we emphasize the critical roles of high-level political will and commitment, respectful and action-oriented partnerships with international agencies, partners, and philanthropies, and the essentiality of strengthening and sustaining the National Public Health Institutes and Digital Health Interventions for future pandemic preparedness, prevention, and response. https://gh.bmj.com/cgi/content/full/bmjgh-2023-014872