Outbreak Update: Since the last brief (15 June 2021), 2,552,079 new confirmed1 coronavirus disease 2019 (COVID-19) cases, including 62,184 new deaths, have been reported globally. To date, a global total of 178,229,144 COVID-19 cases and 3,866,320 related deaths (case fatality ratio (CFR): 2.2%) have been reported from 225 countries and territories to the World Health Organization (WHO). The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 9,225,259 (5%), European Region 55,365,868 (31%), Region of the Americas 70,815,310 (40%), South-East Asia Region 34,110,785 (19%) and Western Pacific Region 3,404,213 (2%). In the last seven days, Brazil reported more than 500,000 new cases, India reported more than 400,000 new cases, while Argentina, Colombia, and the Russian Federation reported more than 100,000 new cases. For more detailed information on cases and deaths reported outside of Africa, refer to the WHO COVID-19 dashboard.2