Outbreak Update: Since the last brief (27 April 2021), 5,690,747 new confirmed coronavirus disease 2019 (COVID-19) cases and 93,812 new deaths have been reported globally. To date, a total of 152,542,447 COVID-19 cases and 3,198,853 related deaths (case fatality ratio (CFR): 2.1%) have been reported from 225 countries and territories. The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 7,898,630 (5%), European Region 52,009,750 (34%), Region of the Americas 62,463,885 (41%), South-East Asia Region 23,060,767 (15%) and Western Pacific Region 2,490,038 (2%). Over the last seven days, India reported more than 2,600,000 new cases, and has reported more than 1,000,000 new cases for the third consecutive week. Brazil, the United States and Turkey each reported more than 200,000 new cases in the past seven days while France, Argentina, Iran, Germany, and Colombia have each reported more than 120,000 new cases during the same period. For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO COVID-19 dashboard.