Outbreak Update: Since the last brief (17 November 2020), 4,123,778 new confirmed1 coronavirus disease 2019 (COVID-19) cases and 68,185 new deaths have been reported globally. To date, a total of 58,436,142 COVID-19 cases and 1,385,469 related deaths (case fatality rate (CFR): 2.4%) have been reported from 221 countries and territories. This week, no new country or territory reported its first case. The distribution of cumulative cases (proportion of global cases) from the World Health Organization (WHO) reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 3,201,382 (5%), European Region 17,063,635 (29%), Region of the Americas 24,815,423 (42%), South-East Asia Region 10,421,539 (18%) and Western Pacific Region 840,703 (1%). Among the affected locations, over the last seven days, the United States has reported more than one million new cases, while Brazil, India and Italy have reported over 200,000 new cases each. For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO daily situation reports.