Since the last brief (14 April 2020), 542,052 new confirmed coronavirus disease 2019 (COVID-19) cases and 46,216 new deaths have been reported globally. This is a 31% increase in cases reported between 14-21 April 2020 compared to a 46% increase in cases reported between 7-14 April 2020. To date, a total of 2,316,039 COVID-19 cases and 157,896 (CFR: 7%) related deaths have been reported worldwide. This week no new countries or territories have reported COVID-19 cases, while two new countries, both African countries, are reporting deaths for the first time. Worldwide, a total of 213 countries and territories have reported COVID-19 cases. The distribution of cumulative cases (proportion of global cases %) from the WHO reporting regions (excluding Africa) are as follows: Eastern Mediterranean Region 121,414 (5%), European Region 1,149,071 (50%), Region of the Americas 858,631 (37%), South- East Asia Region 29,576 (1%) and Western Pacific Region 133,150 (6%). For more detailed information on cases and deaths being reported outside of Africa, refer to the WHO daily situation reports.