Outbreak Update: Since 18 May 2021, no new cases or deaths from Ebola virus disease (EVD) have been reported in Guinea. Cumulatively 23 cases, 12 deaths (CFR: 52%), and 10 recoveries of EVD have been reported. This includes five health workers. The last confirmed EVD case and death was reported on 4 April 2021 (47 days ago). A 42-day countdown was started on 8 May 2021 to declare the end of Guinea’s EVD outbreak (25 days remaining). Guinea continues with viral hemorrhagic fever (VHF) surveillance and on 17 May 2021, the Ministry of Health (MoH) declared an outbreak of Lassa fever in Yamou prefecture, NZérékoré region. A fatal case of Lassa fever was confirmed and no new case has been reported to date. Member States bordering Guinea continue to remain vigilant. Sierra Leone has reported 45 alerts since the onset of EVD in Guinea. Forty-two of these alerts were investigated and tested negative for Ebola virus (but one tested positive for Lassa fever); two were notified after burial.