Outbreak Update: Since 4 May 2021, no new cases or deaths from Ebola virus disease (EVD) have been reported in Guinea. Cumulatively 23 cases of EVD, with 12 deaths (CFR: 52.1%), and 10 recoveries have been reported. This includes five health workers. The last confirmed EVD case and death was reported on 4 April 2021 (35 days ago). A 42-days countdown was officially started on 8 May 2021 to declare the end of Guinea’s EVD outbreak. Member States bordering Guinea continue to remain vigilant. Sierra Leone has reported 44 alerts since the onset of EVD in Guinea. Forty-two were investigated and tested negative for Ebola virus; two were notified after burial.