Member States of the African Union have been implementing various public health initiatives, including strengthening health systems, disease surveillance, control and prevention, and disaster preparedness and response. However, despite significant efforts by countries to contain disease outbreaks and prevent epidemics, the continent is still faced with huge public health challenges, some of which include inadequate health infrastructure, shortage of human resource capacity and equipment, limited disease surveillance, insufficient laboratory diagnostic capacities, and delayed preparedness and response to health emergencies and disasters.